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Symbol Name ID |
Stat3
signal transducer and activator of transcription 3 MGI:103038 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Recurrent upper respiratory tract infections |
Pleural empyema |
Recurrent pneumonia |
Recurrent respiratory infections |
Recurrent sinopulmonary infections |
Pulmonary cyst |
Atelectasis |
Cough |
| Disease(s) Associated with STAT3 | ||||||||
| hyper IgE recurrent infection syndrome 1 |
| Mouse Phenotypes | respiratory system phenotype |
abnormal lung vasculature morphology |
pulmonary epithelial necrosis |
lung inflammation |
abnormal pulmonary alveolus epithelial cell morphology |
decreased type II pneumocyte number |
pulmonary hyaline membrane formation |
increased lung elastance |
increased lung tissue damping |
increased airway resistance |
respiratory distress |
abnormal respiratory mechanics |
decreased lung compliance |
respiratory failure |
abnormal surfactant secretion |
|
| Availability | Mouse Genotype | |||||||||||||||
| Gt(ROSA)26Sortm1(Stat3*A661C*N663C)Sbkv/Gt(ROSA)26Sortm1(Stat3*A661C*N663C)Sbkv Tg(Cd4-cre)1Cwi/0 (conditional) |
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| Stat3tm2Aki/Stat3tm2Aki Tg(SFTPC-rtTA)5Jaw/0 Tg(tetO-cre)1Jaw/0 (conditional) |
* | |||||||||||||||
| Stat3tm1Xyfu/Stat3tm1.1Xyfu Tg(Myh6-cre)2182Mds/0 (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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